https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Clopidogrel Administration Impairs Post-Stroke Learning and Memory Recovery in Mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53239 Wed 28 Feb 2024 15:57:17 AEDT ]]> 20α-Hydroxysteroid Dehydrogenase Expression in the Human Myometrium at Term and Preterm Birth: Relationships to Fetal Sex and Maternal Body Mass Index https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49862 Wed 28 Feb 2024 15:09:16 AEDT ]]> Relationship between levels of pre-stroke physical activity and post-stroke serum insulin-like growth factor I https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45071 p = 0.06) or as a significant effect (ΔIGF-I, p = 0.03) after all the adjustments. Specifically, for each unit of PA, ΔIGF-I increased by 9.7 (95% CI 1,1−18.4) ng/mL after full adjustment. This supports the notion that pre-stroke PA is independently related to ΔIGF-I.]]> Wed 26 Oct 2022 12:29:03 AEDT ]]> Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45041 Wed 26 Oct 2022 12:16:47 AEDT ]]> Impaired microglia process dynamics post-stroke are specific to sites of secondary neurodegeneration https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33097 Wed 19 Jan 2022 15:17:31 AEDT ]]> Chronic stress induced disruption of the peri-infarct neurovascular unit following experimentally induced photothrombotic stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32497 Wed 17 Nov 2021 16:32:12 AEDT ]]> Chronic stress exposure following photothrombotic stroke is associated with increased levels of Amyloid beta accumulation and altered oligomerisation at sites of thalamic secondary neurodegeneration in mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33094 Wed 17 Nov 2021 16:30:26 AEDT ]]> Ontogeny of small RNA in the regulation of mammalian brain development https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15763 Wed 11 Apr 2018 15:11:49 AEST ]]> Is osteoporosis an immune-mediated disorder https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30597 Wed 11 Apr 2018 11:56:53 AEST ]]> Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14891 Wed 11 Apr 2018 11:35:05 AEST ]]> Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25874 Mycobacterium vaccae, an immunoregulatory environmental microorganism, reduced subordinate, flight, and avoiding behavioral responses to a dominant aggressor in a murine model of chronic psychosocial stress when tested 1-2wk following the final immunization. Furthermore, immunization with M. vaccae prevented stress-induced spontaneous colitis and, in stressed mice, induced anxiolytic or fear-reducing effects as measured on the elevated plus-maze, despite stress-induced gut microbiota changes characteristic of gut infection and colitis. Immunization with M. vaccae also prevented stress-induced aggravation of colitis in a model of inflammatory bowel disease. Depletion of regulatory T cells negated protective effects of immunization with M. vaccae on stress-induced colitis and anxiety-like or fear behaviors. These data provide a framework for developing microbiome- and immunoregulation-based strategies for prevention of stress-related pathologies.]]> Wed 11 Apr 2018 10:26:13 AEST ]]> Segmentation of heavily clustered nuclei from histopathological images https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35830 Wed 09 Mar 2022 16:02:34 AEDT ]]> Oral administration of corticosterone at stress-like levels drives microglial but not vascular disturbances post-stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33101 Wed 09 Feb 2022 15:58:21 AEDT ]]> Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33093 Wed 04 Sep 2019 09:56:33 AEST ]]> In the search for integrative biomarker of resilience to psychological stress https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27088 Wed 04 Sep 2019 09:39:52 AEST ]]> Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52178 Wed 04 Oct 2023 11:05:28 AEDT ]]> Leakage beyond the primary lesion: A temporal analysis of cerebrovascular dysregulation at sites of hippocampal secondary neurodegeneration following cortical photothrombotic stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54067 Tue 30 Jan 2024 13:56:39 AEDT ]]> Exploring how low oxygen post conditioning improves stroke-induced cognitive impairment: a consideration of amyloid-beta loading and other mechanisms https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38036 Tue 27 Jul 2021 15:08:13 AEST ]]> Low oxygen post conditioning prevents thalamic secondary neuronal loss caused by excitotoxicity after cortical stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38037 Tue 27 Jul 2021 14:35:35 AEST ]]> Can we use 2,3,5-triphenyltetrazolium chloride-atained brain slices for other purposes? The application of western blotting https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38035 Tue 27 Jul 2021 13:32:27 AEST ]]> Growth hormone treatment promotes remote hippocampal plasticity after experimental cortical stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38034 Tue 27 Jul 2021 12:36:14 AEST ]]> Clinical Decision Support Tools for Predicting Outcomes in Patients Undergoing Total Knee Arthroplasty: A Systematic Review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39822 0.8), and only 2 studies were able to externally validate their developed model. In general, models that performed well used large patient numbers, were tested on similar demographics, and used either nonlinear input transformations or a completely nonlinear model. Conclusion: Some models do show promise; however, there remains the question of whether the reported predictive success can continue to be replicated. Furthermore, clinical applicability and interpretation of predictive tools should be considered during development.]]> Tue 26 Jul 2022 11:57:37 AEST ]]> Galactose-functionalised PCL nanofibre scaffolds to attenuate inflammatory action of astrocytes in vitro and in vivo https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33377 in vitro and in vivo, and have shown, for the first time, the ability of galactose to maintain an attenuated inflammatory profile of astrocytes in culture, and to increase the survival of neurons after traumatic injury, as compared to control PCL nanofibres. This study highlights the importance of galactose in controlling the astrocytic response, and provides a promising biomaterial system to deliver the essential morphological and biological cues to achieve functional repair after traumatic brain injury.]]> Tue 23 Oct 2018 15:31:37 AEDT ]]> Spatiotemporal analysis of impaired microglia process movement at sites of secondary neurodegeneration post-stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48308 2Y12 was present on non-responsive microglia in the first two weeks after stroke but not at later time points. Finally, both classical microglia activation and loss of process extension are highly correlated with neuronal damage. Our findings highlight the importance of microglia, specifically microglia dynamic functions, to the progression of SND post-stroke, and their potential relevance as modulators or therapeutic targets during stroke recovery.]]> Tue 14 Mar 2023 14:41:54 AEDT ]]> Current State and General Perceptions of the Use of Extended Reality (XR) Technology at the University of Newcastle: Interviews and Surveys From Staff and Students https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53631 Tue 12 Dec 2023 15:33:12 AEDT ]]> Segmentation, tracing, and quantification of microglial cells from 3D image stacks https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35829 Tue 10 Dec 2019 15:45:23 AEDT ]]> More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43876 Tue 04 Oct 2022 12:35:43 AEDT ]]> Late gestation immune activation increases IBA1-positive immunoreactivity levels in the corpus callosum of adult rat offspring https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33669 Iba1, Gfap, IL1-β and TNF-α mRNA levels in the cingulate cortex (CC) in adult offspring exposed to maternal immune activation. Prenatal exposure to immune activation had a significant main effect on microglial IBA1-positive immunoreactive material (IBA1+IRM) in the corpus callosum; post-hoc analyses identified a significant increase in GD19 offspring, but not GD10. No change in was observed in the CC. In contrast, maternal immune activation had a significant main effect on GFAP+IRM in the CC at GD19 (not GD10); post-hoc analyses only identified a strong trend towards increased GFAP+IRM in the GD19 offspring, with no white matter changes. This suggests late gestation maternal immune activation causes subtle alterations to microglia and astrocytes in the adult offspring.]]> Tue 04 Jun 2019 13:36:19 AEST ]]> A comparative study of cybersickness during exposure to virtual reality and “classic” motion sickness: are they different? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35487 Thu 30 Jan 2020 13:53:08 AEDT ]]> Regulation of 20α-Hydroxysteroid Dehydrogenase Expression in Term Pregnant Human Myometrium Ex Vivo https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54561 Thu 29 Feb 2024 12:33:44 AEDT ]]> A role for autoantibodies in atherogenesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30598 Thu 28 Oct 2021 13:05:08 AEDT ]]> Habituation of the electrodermal response - a biological correlate of resilience? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45046 Thu 27 Oct 2022 17:36:29 AEDT ]]> Sustained administration of corticosterone at stress-like levels after stroke suppressed glial reactivity at sites of thalamic secondary neurodegeneration https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33100 Thu 17 Mar 2022 14:39:58 AEDT ]]> The copper bis(thiosemicarbazone) complex CuII(atsm) is protective against cerebral ischemia through modulation of the inflammatory milieu https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34330 bis(thiosemicarbazone) complex, CuII (atsm), is beneficial in acute brain injury, in preclinical mouse models of ischemic stroke. We demonstrate that the copper complex CuII (atsm) protects neurons from excitotoxicity and N2a cells from OGD in vitro, and is protective in permanent and transient ischemia models in mice as measured by functional outcome and lesion size. Copper delivery in the ischemic brains modulates the inflammatory response, specifically affecting the myeloid cells. It reduces CD45 and Iba1 immunoreactivity, and alters the morphology of Iba1 positive cells in the ischemic brain. CuII(atsm) also protects endogenous microglia against ischemic insult and reduces the proportion of invading monocytes. These results demonstrate that the copper complex CuII(atsm) is an inflammation-modulating compound with high therapeutic potential in stroke and is a strong candidate for the development of therapies for acute brain injury.]]> Thu 17 Mar 2022 14:35:40 AEDT ]]> Peripheral viral infection induced microglial sensome genes and enhanced microglial cell activity in the hippocampus of neonatal piglets https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24577 Thu 17 Feb 2022 09:27:57 AEDT ]]> Time-efficient intervention to improve older adolescents' cardiorespiratory fitness: findings from the ‘Burn 2 Learn’ cluster randomised controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48041 Thu 16 Feb 2023 13:59:00 AEDT ]]> Growth hormone improves cognitive function after experimental stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33090 Thu 13 Jan 2022 10:30:28 AEDT ]]> Development and Pilot Implementation of TACTICS VR: A Virtual Reality-Based Stroke Management Workflow Training Application and Training Framework https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40631 Thu 11 Aug 2022 09:02:28 AEST ]]> Indexing cerebrovascular health using near-infrared spectroscopy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46046 Thu 10 Nov 2022 09:29:01 AEDT ]]> Neuron image synthesizer via gaussian mixture model and perlin noise https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45858 Thu 08 Dec 2022 10:20:33 AEDT ]]> Visual discrimination impairment after experimental stroke is associated with disturbances in the polarization of the astrocytic aquaporin-4 and increased accumulation of neurotoxic proteins https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38032 Thu 05 Aug 2021 10:35:41 AEST ]]> Low oxygen post conditioning as an efficient non-pharmacological strategy to promote motor function after stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48127 Thu 02 Mar 2023 15:41:40 AEDT ]]> Strain differences in coping behaviour, novelty seeking behaviour, and susceptibility to socially conditioned fear: a comparison between Wistar and Sprague Dawley rats https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8332 Sat 24 Mar 2018 08:36:58 AEDT ]]> Neonatal bacterial endotoxin challenge interacts with stress in the adult male rat to modify KLH specific antibody production but not KLH stimulated ex vivo cytokine release https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8145 Sat 24 Mar 2018 08:36:07 AEDT ]]> A profile of the immediate endocrine, metabolic and behavioural responses following a dual exposure to endotoxin in early life https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1924 Sat 24 Mar 2018 08:33:09 AEDT ]]> Early life host-bacteria relations and development: long-term individual differences in neuroimmune function following neonatal endotoxin challenge https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1358 Sat 24 Mar 2018 08:32:41 AEDT ]]> Neonatal endotoxin exposure influences HPA responsivity and impairs tumour immunity in Fischer 344 rats in adulthood https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1343 Sat 24 Mar 2018 08:32:36 AEDT ]]> Individual differences in glucose homeostasis: do our early life interactions with bacteria matter? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1173 Sat 24 Mar 2018 08:28:27 AEDT ]]> The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12480 Sat 24 Mar 2018 08:17:19 AEDT ]]> Metyrapone and fluoxetine suppress enduring behavioral but not cardiac effects of subchronic stress in rats https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13287 Sat 24 Mar 2018 08:16:04 AEDT ]]> Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10881 Sat 24 Mar 2018 08:11:33 AEDT ]]> Voluntary exercise does not affect stress-induced tachycardia, but improves resistance to cardiac arrhythmias in rats https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12260 2, respectively (P < 0.05 for 2 h runners vs controls), whereas intrinsic HR was 383 ± 3, 377 ± 2 and 346 ± 3 b.p.m., respectively (P < 0.001 for 2 h runners vs controls). Restraint stress provoked tachycardia of similar magnitude in all groups. 4. After completion of telemetric studies, haemodynamic indices and susceptibility to cardiac arrhythmias were assessed in anaesthetized animals, there were no major between-group differences in HR, arterial pressure, contractility indices or sensitivity to β-adrenoceptor stimulation (dobutamine) or blockade (atenolol). The effective refractory period in the control rats, 24 h runners and 2 h runners was 49 ± 2, 55 ± 2 and 60 ± 4 ms, respectively (P = 0.054 for 2 h runners vs controls). A significantly higher dose of aconitine was required to provoke ventricular arrhythmias in the 24 h and 2 h running groups compared with controls (489 ± 76, 505 ± 88 and 173 ± 33 μg, respectively; P < 0.05). 5. We conclude that, in rats, long-term voluntary exercise has enduring cardioprotective effects mediated at the level of both the central nervous system and the heart.]]> Sat 24 Mar 2018 08:08:11 AEDT ]]> Respiratory pattern in awake rats: effects of motor activity and of alerting stimuli https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10147 Sat 24 Mar 2018 08:07:28 AEDT ]]> Stress as necessary component of realistic recovery in animal models of experimental stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20536 Sat 24 Mar 2018 08:02:43 AEDT ]]> Chronic stress-induced disruption of the astrocyte network is driven by structural atrophy and not loss of astrocytes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20073 Sat 24 Mar 2018 08:00:11 AEDT ]]> Does exposure to chronic stress influence blood pressure in rats? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18932 Sat 24 Mar 2018 07:58:58 AEDT ]]> Neonatal endotoxin exposure modifies the acoustic startle response and circulating levels of corticosterone in the adult rat but only following acute stress https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5524 Sat 24 Mar 2018 07:46:40 AEDT ]]> Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27631 Sat 24 Mar 2018 07:34:04 AEDT ]]> Photothrombotic stroke induces persistent ipsilateral and contralateral astrogliosis in key cognitive control nuclei https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28942 p < 0.05), as defined by a marked elevation in GFAP expression, within all 13 sites assessed within the ipsilateral (lesioned) hemisphere. We further observed significant increases in GFAP expression (p < 0.05) in 9 of the 13 contralesional sites examined. This work underscores that both the ipsilateral and contralesional hemispheres, at sites distal to the infarct, are very active many weeks after the initial occlusion, a finding that potentially has significant implications for understanding and improving the regeneration of the damaged brain.]]> Sat 24 Mar 2018 07:31:25 AEDT ]]> In the search for integrative biomarker of resilience to psychological stress https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30855 Sat 24 Mar 2018 07:26:36 AEDT ]]> Individual differences predict susceptibility to conditioned fear arising from psychosocial trauma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4889 Sat 24 Mar 2018 07:21:59 AEDT ]]> Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24954 KO astrocytes did not augment transforming growth factor β after immune challenge and failed to resolve microglial activation. Collectively, a major cytokine-regulatory loop between activated microglia and astrocytes is impaired in the aged brain.]]> Sat 24 Mar 2018 07:14:18 AEDT ]]> A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23164 Sat 24 Mar 2018 07:10:28 AEDT ]]> Chronic stress induced disturbances in Laminin: a significant contributor to modulating microglial pro-inflammatory tone? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33098 Mon 27 Aug 2018 12:12:48 AEST ]]> Feasibility of biomarkers to measure stress, burnout and fatigue in emergency nurses: a cross-sectional study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51980 Mon 25 Sep 2023 12:09:03 AEST ]]> Similar cognitive deficits in mice and humans in the chronic phase post-stroke identified using the touchscreen-based paired-associate learning task https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42362 Mon 22 Aug 2022 14:08:28 AEST ]]> Clopidogrel Administration Impairs Post-Stroke Learning and Memory Recovery in Mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50905 Mon 13 Nov 2023 08:50:41 AEDT ]]> Age-dependent Disturbances of Neuronal and Glial Protein Expression Profiles in Areas of Secondary Neurodegeneration Post-stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43040 Mon 12 Sep 2022 12:10:20 AEST ]]> Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38402 Mon 06 Sep 2021 16:41:33 AEST ]]> A cross-sectional study of the association between autoantibodies and qualitative ultrasound index of bone in an elderly sample without clinical autoimmune disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42827 Mon 05 Sep 2022 11:56:26 AEST ]]> Corticosterone administration alters white matter tract structure and reduces gliosis in the sub-acute phase of experimental stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40655 Fri 22 Jul 2022 14:02:02 AEST ]]> Cybersickness-related changes in brain hemodynamics: a pilot study comparing transcranial Doppler and near-infrared spectroscopy assessments during a virtual ride on a roller coaster https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35486 Fri 16 Aug 2019 13:43:22 AEST ]]> Growth hormone promotes motor function after experimental stroke and enhances recovery-promoting mechanisms within the peri-infarct Area https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38033 Fri 15 Jul 2022 10:39:21 AEST ]]> Abrogation of type-I interferon signalling alters the microglial response to Aß<sub>1-42</sub> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44488 1–42 exposure increases bioactive levels of type-I IFN produced by primary microglia alongside increased expression of type-I IFN related genes. Primary microglia isolated from brains of APPswePS1ΔE9 mice with ablated type-I IFN signalling show an increased phagocytic ability to uptake FITC-Aβ1–42. Correlative assessment of plaque sizes in aged APPswePS1ΔE9 mice with abrogated type-I IFN signalling show unchanged deposition levels. Microglia from these mice did however show alterations in morphology. This data further highlights the role of type-I IFN signalling within microglia and identifies a role in phagocytosis. As such, targeting both microglial and global type-I IFN signalling presents as a novel therapeutic strategy for AD management.]]> Fri 14 Oct 2022 09:11:35 AEDT ]]>